EM 163

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

EM-163 是一种合成的 BB-Loop 模拟物。EM-163 可以通过靶向 MyD88 的 TIR 结构域，缓解炎症并防止中毒性休克导致的死亡。EM-163 可以用于 SEB 中毒的研究 (SEB: 葡萄球菌肠毒素 B)。

EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B).

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Animal Model:SEB-induced BALB/c mice model Dosage:0.21 mg/mouse, 0.42 mg/mouse, 0.86 mg/mouse Administration:Intraperitoneal injection (i.p.); Single dose. Before SEB treatment (0.5 μg/mouse, 5 μg/mouse; i.p.; single dose) and LPS treatment.Result:Delayed mouse death at a dose of 0.21 mg/mouse, and protected mice from death at either dose of 0.42 mg/mouse or 0.86 mg/mouse.Delayed mouse death even at high doses of SEB (5 μg).

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Immunology/Inflammation

MyD88

MyD88 | p38 MAPK | IL Receptor

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1206480-93-4

849.88

C44H60IN5O4

>98% (HPLC)

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N([C@H](C(=O)N1CCCC1)C(C)C)(C(=O)C2=C[N+](C)=C(C(N([C@H](C(=O)N3CCCC3)C(C)C)CCCC4=CC=CC=C4)=O)C=C2)CCCC5=CC=CC=C5.[I-]

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(-20℃)

With Ice Pack

≥ 2 years